Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 2
Species	Homo sapiens (Human)
Gene	GABBR2
Synonym	HG20 GPRC3B GPR51 Gb2 gamma-aminobutyric acid (GABA) B receptor, 2 gamma-aminobutyric acid (GABA) B receptor 2 gamma-aminobutyric acid (GABA) B receptor GABABR2 GABAB2 GABA-BR2 GABA-B-R2 GABA-B R2 receptor G-protein coupled receptor 51 G protein-coupled receptor 51 GABA-B receptor 2 [ Show all ]
Disease	Pain Drug abuse Fragile X syndrome Nicotine dependence Partial seizures Depression Cancer Schizophrenia Absence seizures Anxiety disorder [ Show all ]
Length	941
Amino acid sequence	MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
UniProt	O75899
Protein Data Bank	4mr7, 4mr8
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mr7.
BioLiP	BL0264360, BL0264364, BL0264363, BL0264362, BL0264361
Therapeutic Target Database	T42446
ChEMBL	N/A
IUPHAR	N/A
DrugBank	BE0002340

Ligand

Name	4-aminobutyric acid
Molecular formula	C4H9NO2
IUPAC name	4-aminobutanoic acid
Molecular weight	103.121
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-3.2
Synonyms	178648-EP2269992A1 CHEMBL96 3131-86-0 4-amino-n-butyric acid DTXSID6035106 4-Aminobutyric acid, 99+% Gaballon A 2129 GAMMA-AMINO-BUTANOIC ACID Acide amino-4- butyrique [French] gamma-aminobutyric acid Aminalone Gamma-Aminobutyric Acid,(S) BDBM24183 BSPBio_002970 13511-EP2272537A2 Butyric acid, 4-amino- (7CI,8CI) SPBio_000996 KBio2_000429 SR-01000075618-1 KSC269S7N TL8006100 MCULE-7613134021 UNII-2ACZ6IPC6I NCGC00015043-03 [3H]GABA NCGC00024546-01 NINDS_000616 NSC32044 PDSP1_001275 Globulin, immune human serum RTR-019733 I04-0182 CAS-56-12-2 178648-EP2277865A1 CS-W020704 33777-EP2311453A1 DivK1c_000616 4-Aminobutanoic acid EU-0100005 4Abu Gamastan AB00052155_12 gamma-Aminobutryic acid AJ-26795 gamma-Aminobutyric acid, >=99% AN-24434 Gammalon (TN) bmse000820 .gamma.-Aminobutanoic acid Butanoic acid, 4-amino- (9CI) 13511-EP2298766A1 Spectrum3_001385 KBio3_002190 SR-01000075618-7 Lopac-A-2129 Tox21_110071 Mielomade w-Aminobutyrate NCGC00015043-06 NCGC00024546-04 NSC-32044 NSC757426 Piperidic acid GTPL5410 SBI-0049994.P003 Immu-G 13511-EP2314571A2 CHEBI:16865 2ACZ6IPC6I D0C9XA 4-AMINO-BUTYRATE DSSTox_GSID_35106 4-Aminobutyric g-Aminobutyric acid 6610-05-5 (mono-hydrochloride salt) GAMMA(AMINO)-BUTYRIC ACID AC1Q54DP gamma-Aminobuttersaure AM20100372 gamma-Aminobutyric acid, certified reference material, TraceCERT(R) BBL008590 BR-43987 Butanoicacid, 4-amino- KB-62456 Spectrum_000049 KS-000048O9 STK301748 LS-47805 TR-019733 NCGC00015043-01 Z955123658 NCGC00015043-09 NCGC00260690-01 NSC-757426 Opera_ID_1152 Gammasol Reanal HMS3260A11 SGCUT00121 C00334 178648-EP2270002A1 Chemical Name: .gamma.-Aminobutanoic acid 33777-EP2286811A1 DB02530 4-amino-n-[2,3-3H]butyric acid EINECS 200-258-6 4-NH2-but gam.-Aminobutyric acid a-Aminobutyric acid gamma-amino-n-butyric acid ACMC-1CAQ1 gamma-Aminobutyric acid (JAN) Aminobutanoic acid Gammagee Biomol-NT_000230 .gamma.-Amino-butyric acid BTCSSZJGUNDROE-UHFFFAOYSA-N 13511-EP2275401A1 SPECTRUM1500678 KBio2_002997 SR-01000075618-3 L000262 TL806167 MFCD00008226 Vigabatrin EP Impurity D NCGC00015043-04 NCGC00024546-02 NSC 27418 NSC45460 PDSP2_001259 GSK683699 s4700 I04-1117 CCG-38515 20-79-1 CTK1G9976 4-amino butyric acid DL-gamma-AMINO-n-BUTYRIC ACID 4-Aminobutylate F2191-0196 56-12-2 Gamma aminobutyrate AB1003088 gamma-Aminobuttersaeure AK-43987 gamma-Aminobutyric acid, analytical standard ANW-13573 bmse000871 .gamma.-Aminobutyric acid BUTANOIC ACID,4-AMINO 13511-EP2298776A1 Immuglobin Spectrum4_000809 KBioGR_001297 ST2411110 Lopac0_000005 Tox21_500005 MLS000028505 w-Aminobutyric acid NCGC00015043-07 NCGC00024546-05 NSC-45460 omega-Aminobutyrate Gammalone Piperidinate HMS1921C06 SC-10045 13511-EP2316836A1 3-Carboxypropylamine D0D3ID 4-Amino-butyric acid DSSTox_RID_79238 GABA 70582-09-1 (calcium salt (2:1)) gamma-Amino butyric acid Acide amino-4- butyrique gamma-aminobutyrate Aminalon gamma-Aminobutyric acid, United States Pharmacopeia (USP) Reference Standard BC204189 BRD-K77245796-001-19-2 13511-EP2269989A1 Butyric acid, 4-amino- KBio1_000616 SR-01000075618 KS-5273 STR01523 M-7233 TRA0094659 NCGC00015043-02 ZINC1532620 NCGC00015043-10 NH2-(CH2)3-COOH NSC27418 Oprea1_584567 Gamulin RP18806 HMS501O18 SMR000058285 C5C3DC27-C105-4D18-8A52-F51978B32D24 178648-EP2275102A1 cid_119 33777-EP2295055A2 DF 468 4-aminobutanoate EPA Pesticide Chemical Code 030802 4-NH3-but Gamarex A0282 gamma-Aminobutanoic acid AI3-26812 Gamma-aminobutyric acid [JAN] Aminobutyric acid,-4- Gammalon bmse000340 .gamma.-Amino-N-butyric acid butanoic acid, 4-amino- 13511-EP2292222A1 Spectrum2_001208 KBio2_005565 SR-01000075618-6 LMFA01100039 Tocris-0344 Mielogen Vigabatrin impurity D, European Pharmacopoeia (EP) Reference Standard NCGC00015043-05 NCGC00024546-03 NSC-27418 NSC51295 Pharmakon1600-01500678 GTPL1067 SBB028179 IDI1_000616 13511-EP2308875A1 CCRIS 3721 D00058 4-amino-butanoic acid DSSTox_CID_15106 4-aminobutyrate FT-0617569 5959-35-3 (hydrochloride) gamma Aminobutyric acid AC1L18IR gamma-Aminobuttersaeure [German] AKOS000119660 gamma-Aminobutyric acid, BioXtra, >=99% ARONIS27190 BP-21452 .omega.-Aminobutyric acid BUTANOIC ACID,4-AMINO 4-AMINO,BUTYRIC ACID InChI=1/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7 Spectrum5_001425 KBioSS_000429 ST45061580 LP00005 to_000021 MolPort-000-146-216 WLN: Z3VQ NCGC00015043-08 NCGC00024546-06 NSC-51295 omega-Aminobutyric acid Gammar Piperidinic acid HMS2232P09 SCHEMBL4878 [ Show all ]
Inchi Key	BTCSSZJGUNDROE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
PubChem CID	119
ChEMBL	CHEMBL96
IUPHAR	1067
BindingDB	24183
DrugBank	DB02530
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417