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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 4
Species	Homo sapiens (Human)
Gene	S1PR4
Synonym	S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 Endothelial differentiation G-protein coupled receptor 6 edg6 Sphingosine 1-phosphate receptor Edg-6 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
UniProt	O95977
Protein Data Bank	N/A
GPCR-HGmod model	O95977
3D structure model	This predicted structure model is from GPCR-EXP O95977.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3230
IUPHAR	278
DrugBank	N/A

Ligand

Name	CHEMBL3885401
Molecular formula	C20H21NO2S
IUPAC name	4-[[7-(2-methylphenyl)-1-benzothiophen-2-yl]methylamino]butanoic acid
Molecular weight	339.453
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.9
Synonyms	BDBM50209064
Inchi Key	FAQQWLOPBMREGY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21NO2S/c1-14-6-2-3-8-17(14)18-9-4-7-15-12-16(24-20(15)18)13-21-11-5-10-19(22)23/h2-4,6-9,12,21H,5,10-11,13H2,1H3,(H,22,23)
PubChem CID	134131399
ChEMBL	CHEMBL3885401
IUPHAR	N/A
BindingDB	50209064
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	13500.0 nM	PMID27894870	BindingDB,ChEMBL

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