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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	MLS000052086
Molecular formula	C19H16N4S
IUPAC name	6-(2,3-dihydroindol-1-ylmethyl)-3-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazole
Molecular weight	332.425
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.6
Synonyms	ChemDiv2_006169 MolPort-000-630-602 6-(indolin-1-ylmethyl)-3-phenyl-thiazolo[2,3-c][1,2,4]triazole HMS2481I20 ZINC1061334 1-[(3-phenyl[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)methyl]indoline BAS 12335539 CHEBI:105005 6-(2,3-dihydroindol-1-ylmethyl)-3-phenyl-[1,3]thiazolo[2,3-c][1,2,4]triazole cid_1251408 SMR000081396 1-(3-Phenyl-thiazolo[2,3-c][1,2,4]triazol-6-ylmethyl)-2,3-dihydro-1H-indole AC1LNRY0 IDI1_004884 BDBM48952 CHEMBL1594844 MLS000116435 6-(2,3-dihydroindol-1-ylmethyl)-3-phenylthiazolo[2,3-c][1,2,4]triazole HMS1386I09 STL012012 1-[(3-phenyl[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)methyl]-2,3-dihydro-1H-indole AKOS001815684 CCG-128053 MCULE-8819389198 6-(2,3-dihydro-1H-indol-1-ylmethyl)-3-phenyl[1,3]thiazolo[2,3-c][1,2,4]triazole [ Show all ]
Inchi Key	CZEOVHGKEIYKCI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H16N4S/c1-2-7-15(8-3-1)18-20-21-19-23(18)13-16(24-19)12-22-11-10-14-6-4-5-9-17(14)22/h1-9,13H,10-12H2
PubChem CID	1251408
ChEMBL	N/A
IUPHAR	N/A
BindingDB	48952
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.0118 nM	N/A	BindingDB

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