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Name | Chemokine-like receptor 1 |
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Species | Homo sapiens (Human) |
Gene | CMKLR1 |
Synonym | tazarotene induced gene 2 receptor RVER1 resolvin E1 receptor Gpcr27 G-protein coupled receptor DEZ [ Show all ] |
Disease | N/A |
Length | 373 |
Amino acid sequence | MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML |
UniProt | Q99788 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99788 |
3D structure model | This predicted structure model is from GPCR-EXP Q99788. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3540 |
IUPHAR | 79 |
DrugBank | N/A |
Name | CHEMBL3926348 |
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Molecular formula | C31H35F6N3O4 |
IUPAC name | tert-butyl 4-[3-[[3,5-bis(trifluoromethyl)phenyl]carbamoyl]-1-(2,6-dimethylphenyl)-5-oxopyrrolidin-3-yl]piperidine-1-carboxylate |
Molecular weight | 627.628 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 1 |
XlogP | 5.8 |
Synonyms | SCHEMBL12728459 |
Inchi Key | HUQGOWJXRXYNBV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C31H35F6N3O4/c1-18-7-6-8-19(2)25(18)40-17-29(16-24(40)41,20-9-11-39(12-10-20)27(43)44-28(3,4)5)26(42)38-23-14-21(30(32,33)34)13-22(15-23)31(35,36)37/h6-8,13-15,20H,9-12,16-17H2,1-5H3,(H,38,42) |
PubChem CID | 51033568 |
ChEMBL | CHEMBL3926348 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 30.0 nM | None | ChEMBL |
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