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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL181251
Molecular formula	C23H23BrF3N5O2
IUPAC name	[4-bromo-2-(trifluoromethoxy)phenyl]-[4-[[4-(dimethylamino)quinazolin-2-yl]amino]piperidin-1-yl]methanone
Molecular weight	538.369
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	5.9
Synonyms	BDBM50170188 SCHEMBL13793628 (4-Bromo-2-trifluoromethoxy-phenyl)-[4-(4-dimethylamino-quinazolin-2-ylamino)-piperidin-1-yl]-methanone
Inchi Key	AHAIAGUVLZQAPM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23BrF3N5O2/c1-31(2)20-16-5-3-4-6-18(16)29-22(30-20)28-15-9-11-32(12-10-15)21(33)17-8-7-14(24)13-19(17)34-23(25,26)27/h3-8,13,15H,9-12H2,1-2H3,(H,28,29,30)
PubChem CID	44390748
ChEMBL	CHEMBL181251
IUPHAR	N/A
BindingDB	50170188
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1200.0 nM	PMID16002290	BindingDB,ChEMBL

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