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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prolactin-releasing peptide receptor
Species	Homo sapiens (Human)
Gene	PRLHR
Synonym	PrRP receptor hGR3 GPR10 G-protein coupled receptor 10 G protein-coupled receptor 10 PrRPR [ Show all ]
Disease	N/A
Length	370
Amino acid sequence	MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProt	P49683
Protein Data Bank	N/A
GPCR-HGmod model	P49683
3D structure model	This predicted structure model is from GPCR-EXP P49683.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1681611
IUPHAR	337
DrugBank	N/A

Ligand

Name	SCHEMBL437465
Molecular formula	C26H25F3N6O3S
IUPAC name	3-methoxy-6-(1-methyl-5-thiophen-2-ylpyrazole-3-carbonyl)-2-[1-[4-(trifluoromethyl)phenyl]ethylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one
Molecular weight	558.58
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	3.1
Synonyms	BDBM195702 US9206173, 2464 CHEMBL3915574
Inchi Key	FUIRXOGPVHEATL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H25F3N6O3S/c1-15(16-6-8-17(9-7-16)26(27,28)29)30-25-31-19-10-11-34(14-18(19)23(36)35(25)38-3)24(37)20-13-21(33(2)32-20)22-5-4-12-39-22/h4-9,12-13,15H,10-11,14H2,1-3H3,(H,30,31)
PubChem CID	66686131
ChEMBL	CHEMBL3915574
IUPHAR	N/A
BindingDB	195702
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	20.0 nM	, None	BindingDB,ChEMBL

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