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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000761483
Molecular formula	C20H19ClN2O
IUPAC name	7-[(2-chlorophenyl)-pyrrolidin-1-ylmethyl]quinolin-8-ol
Molecular weight	338.835
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.5
Synonyms	7-[(2-chlorophenyl)-pyrrolidin-1-yl-methyl]quinolin-8-ol Oprea1_225050 7-[(2-chlorophenyl)pyrrolidinylmethyl]quinolin-8-ol HMS2681I13 ST50037288 7-[(2-chlorophenyl)(pyrrolidin-1-yl)methyl]quinolin-8-ol AKOS016290438 MCULE-5091568330 7-[(2-chlorophenyl)-pyrrolidin-1-ylmethyl]quinolin-8-ol CHEMBL1585527 Oprea1_813706 AC1NPY8G KSC-335-034 STL305051 7-[(2-chlorophenyl)-(1-pyrrolidinyl)methyl]-8-quinolinol BDBM64703 7-[(2-chlorophenyl)-pyrrolidino-methyl]quinolin-8-ol cid_5187118 SMR000371583 AKOS000807942 KUC112871N [ Show all ]
Inchi Key	AATWULBPEFPAGD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19ClN2O/c21-17-8-2-1-7-15(17)19(23-12-3-4-13-23)16-10-9-14-6-5-11-22-18(14)20(16)24/h1-2,5-11,19,24H,3-4,12-13H2
PubChem CID	5187118
ChEMBL	CHEMBL1585527
IUPHAR	N/A
BindingDB	64703
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	3548.1 nM	PubChem BioAssay data set	ChEMBL

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