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GPCR

NameProlactin-releasing peptide receptor
SpeciesHomo sapiens (Human)
GenePRLHR
SynonymPrRP receptor
hGR3
GPR10
G-protein coupled receptor 10
G protein-coupled receptor 10
[ Show all ]
DiseaseN/A
Length370
Amino acid sequenceMASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProtP49683
Protein Data BankN/A
GPCR-HGmod modelP49683
3D structure modelThis predicted structure model is from GPCR-EXP P49683.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1681611
IUPHAR337
DrugBankN/A

Ligand

NameSCHEMBL452039
Molecular formulaC23H21Cl2F3N4O3
IUPAC name6-(4-chlorobenzoyl)-3-methoxy-2-[[4-(trifluoromethyl)phenyl]methylamino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one;hydrochloride
Molecular weight529.341
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogPNone
SynonymsCHEMBL3727878
Inchi KeyORHYAGINPZTTLT-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H20ClF3N4O3.ClH/c1-34-31-21(33)18-13-30(20(32)15-4-8-17(24)9-5-15)11-10-19(18)29-22(31)28-12-14-2-6-16(7-3-14)23(25,26)27;/h2-9H,10-13H2,1H3,(H,28,29);1H
PubChem CID66690150
ChEMBLCHEMBL3727878
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki39.0 nMNoneChEMBL

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