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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prolactin-releasing peptide receptor
Species	Homo sapiens (Human)
Gene	PRLHR
Synonym	PrRP receptor hGR3 GPR10 G-protein coupled receptor 10 G protein-coupled receptor 10 PrRPR [ Show all ]
Disease	N/A
Length	370
Amino acid sequence	MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProt	P49683
Protein Data Bank	N/A
GPCR-HGmod model	P49683
3D structure model	This predicted structure model is from GPCR-EXP P49683.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1681611
IUPHAR	337
DrugBank	N/A

Ligand

Name	SCHEMBL435882
Molecular formula	C29H29F3N4O2
IUPAC name	3-but-2-ynyl-6-(3,4-dimethylbenzoyl)-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one
Molecular weight	522.572
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.4
Synonyms	BDBM195685 US9206173, 2447 CHEMBL3729362
Inchi Key	HYAGGHWWMQKQAA-FQEVSTJZSA-N
Inchi ID	InChI=1S/C29H29F3N4O2/c1-5-6-14-36-27(38)24-17-35(26(37)22-8-7-18(2)19(3)16-22)15-13-25(24)34-28(36)33-20(4)21-9-11-23(12-10-21)29(30,31)32/h7-12,16,20H,13-15,17H2,1-4H3,(H,33,34)/t20-/m0/s1
PubChem CID	66685767
ChEMBL	CHEMBL3729362
IUPHAR	N/A
BindingDB	195685
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	41.0 nM	, None	BindingDB,ChEMBL

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