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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 1
Species	Homo sapiens (Human)
Gene	GALR1
Synonym	GAL1-R GALNR GALNR1 GALR-1 GAL1 receptor
Disease	Epileptic seizures
Length	349
Amino acid sequence	MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProt	P47211
Protein Data Bank	N/A
GPCR-HGmod model	P47211
3D structure model	This predicted structure model is from GPCR-EXP P47211.
BioLiP	N/A
Therapeutic Target Database	T78581
ChEMBL	CHEMBL4894
IUPHAR	243
DrugBank	N/A

Ligand

Name	CHEMBL1922023
Molecular formula	C28H29FN6O2
IUPAC name	4-N-(3-fluoro-4-methoxyphenyl)-2-N-(4-methoxyphenyl)-6-(4-phenylpiperazin-1-yl)pyrimidine-2,4-diamine
Molecular weight	500.578
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	6.0
Synonyms	BDBM50358671 SCHEMBL10143486
Inchi Key	CWWZPFTWUMPNAY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H29FN6O2/c1-36-23-11-8-20(9-12-23)31-28-32-26(30-21-10-13-25(37-2)24(29)18-21)19-27(33-28)35-16-14-34(15-17-35)22-6-4-3-5-7-22/h3-13,18-19H,14-17H2,1-2H3,(H2,30,31,32,33)
PubChem CID	57390718
ChEMBL	CHEMBL1922023
IUPHAR	N/A
BindingDB	50358671
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6820.0 nM	PMID22018787	BindingDB,ChEMBL
Inhibition	60.0 %	PMID22018787	ChEMBL

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