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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3718107
Molecular formulaC24H28F4N6O3
IUPAC name3-[4-[(2-fluoro-4-methoxyphenyl)methyl]piperidin-1-yl]-N-propan-2-ylpyrazino[2,3-d]pyridazin-2-amine;2,2,2-trifluoroacetic acid
Molecular weight524.521
Hydrogen bond acceptor13
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyHBLOMXJYRARWKP-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H27FN6O.C2HF3O2/c1-14(2)26-21-22(28-20-13-25-24-12-19(20)27-21)29-8-6-15(7-9-29)10-16-4-5-17(30-3)11-18(16)23;3-2(4,5)1(6)7/h4-5,11-15H,6-10H2,1-3H3,(H,26,27);(H,6,7)
PubChem CID127024565
ChEMBLCHEMBL3718107
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC5015.0 nMNoneChEMBL

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