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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL3759944
Molecular formulaC25H39ClN4O4
IUPAC name4-amino-5-chloro-N-[(3R,4S)-1-[[1-(2,2-dimethylpropanoyl)piperidin-4-yl]methyl]-3-methoxypiperidin-4-yl]-2-methoxybenzamide
Molecular weight495.061
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.9
SynonymsFNMBJONFSYMEGN-RBBKRZOGSA-N
SCHEMBL3316704
BDBM50142920
cis-4-amino-5-chloro-N-[1-((1-pivaloylpiperidin-4-yl)methyl)-3-methoxypiperidin-4-yl]-2-methoxybenzamide
Inchi KeyFNMBJONFSYMEGN-RBBKRZOGSA-N
Inchi IDInChI=1S/C25H39ClN4O4/c1-25(2,3)24(32)30-10-6-16(7-11-30)14-29-9-8-20(22(15-29)34-5)28-23(31)17-12-18(26)19(27)13-21(17)33-4/h12-13,16,20,22H,6-11,14-15,27H2,1-5H3,(H,28,31)/t20-,22+/m0/s1
PubChem CID68592173
ChEMBLCHEMBL3759944
IUPHARN/A
BindingDB50142920
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50100.0 nMPMID26761776BindingDB,ChEMBL

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