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GPCR

NameProlactin-releasing peptide receptor
SpeciesHomo sapiens (Human)
GenePRLHR
SynonymPrRP receptor
hGR3
GPR10
G-protein coupled receptor 10
G protein-coupled receptor 10
[ Show all ]
DiseaseN/A
Length370
Amino acid sequenceMASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVIVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWPRKIAPHGQNMTVSVVI
UniProtP49683
Protein Data BankN/A
GPCR-HGmod modelP49683
3D structure modelThis predicted structure model is from GPCR-EXP P49683.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1681611
IUPHAR337
DrugBankN/A

Ligand

NameCHEMBL3729141
Molecular formulaC28H25F3N6O2
IUPAC name6-(1H-benzimidazole-2-carbonyl)-3-but-3-ynyl-2-[[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-one
Molecular weight534.543
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP3.5
SynonymsBDBM195696
US9206173, 2458
Inchi KeyFGRPFJFQVPSNQU-KRWDZBQOSA-N
Inchi IDInChI=1S/C28H25F3N6O2/c1-3-4-14-37-25(38)20-16-36(26(39)24-33-22-7-5-6-8-23(22)34-24)15-13-21(20)35-27(37)32-17(2)18-9-11-19(12-10-18)28(29,30)31/h1,5-12,17H,4,13-16H2,2H3,(H,32,35)(H,33,34)/t17-/m0/s1
PubChem CID91294298
ChEMBLCHEMBL3729141
IUPHARN/A
BindingDB195696
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki245.0 nM, NoneBindingDB,ChEMBL

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