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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1B) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD5
Synonym	Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor D5 receptor D1beta dopamine receptor D(5) dopamine receptor D(1B) dopamine receptor [ Show all ]
Disease	Solid tumours Schizophrenia
Length	477
Amino acid sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProt	P21918
Protein Data Bank	N/A
GPCR-HGmod model	P21918
3D structure model	This predicted structure model is from GPCR-EXP P21918.
BioLiP	N/A
Therapeutic Target Database	T46828
ChEMBL	CHEMBL1850
IUPHAR	218
DrugBank	BE0000145, BE0004889

Ligand

Name	1-Benzylpyrrolidine
Molecular formula	C11H15N
IUPAC name	1-benzylpyrrolidine
Molecular weight	161.248
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	2.2
Synonyms	DA-07223 MCULE-8241404624 SC-70526 29897-82-3 BDBM50384283 EINECS 249-936-3 N-Benzylpyrrolidine ST50405825 1-(Benzyl)pyrrolidine AC1L3UPD CHEMBL2030631 CTK4G4015 KB-301833 Pyrrolidine, 1-benzyl- ZINC2581987 AK140155 DS-6821 MolPort-002-476-207 SCHEMBL13952 4CH-017081 benzylpyrrolidine CL2811 FT-0607388 pyrrolidin-1-ylmethyl benzene STK116065 1-(Phenylmethyl)pyrrolidine AC1Q1H0W CWEGCQIIDCZZED-UHFFFAOYSA-N KS-00000GRK Pyrrolidine,1-(phenylmethyl)- 1-Benzylpyrrolidine # AKOS005399424 DTXSID30184009 N-benzyl-pyrrolidine ST2403329 AB0070192 CS-0031418 KB-152174 Pyrrolidine, 1-(phenylmethyl)- X-2935 1-BENZYL-PYRROLIDINE AJ-43053 [ Show all ]
Inchi Key	CWEGCQIIDCZZED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H15N/c1-2-6-11(7-3-1)10-12-8-4-5-9-12/h1-3,6-7H,4-5,8-10H2
PubChem CID	122501
ChEMBL	CHEMBL2030631
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>50.0 %	PMID22607684	ChEMBL

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