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GLASS

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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1615032
Molecular formula	C21H18FNO4S
IUPAC name	4-[[benzenesulfonyl-[(2-fluorophenyl)methyl]amino]methyl]benzoic acid
Molecular weight	399.436
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.7
Synonyms	US9247759, 5-103 CHEMBL3907807 US9247759, 5-155 BDBM211161
Inchi Key	GLZJPRAWXKLWRY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H18FNO4S/c22-20-9-5-4-6-18(20)15-23(28(26,27)19-7-2-1-3-8-19)14-16-10-12-17(13-11-16)21(24)25/h1-13H,14-15H2,(H,24,25)
PubChem CID	57422394
ChEMBL	CHEMBL3907807
IUPHAR	N/A
BindingDB	211161
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	429.0 nM	None	ChEMBL
IC50	429.0 nM	N/A	BindingDB

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