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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 6
Species	Rattus norvegicus (Rat)
Gene	Grm6
Synonym	nob3 nob2 nerg1 mGluR6 mGlu6 receptor Gprc1f glutamate receptor nob4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	871
Amino acid sequence	MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
UniProt	P35349
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3842
IUPHAR	294
DrugBank	N/A

Ligand

Name	D-AP4
Molecular formula	C4H10NO5P
IUPAC name	(2R)-2-amino-4-phosphonobutanoic acid
Molecular weight	183.1
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-5.5
Synonyms	FT-0772107 NCGC00024466-01 Tocris-0102 AKOS024456336 CHEMBL1319383 D-(-)-2-Amino-4-phosphonobutyric acid Lopac-A-1910 PDSP2_000359 (r)-2-amino-4-phosphonobutyric acid BDBM82006 D0G7TT NCGC00015041-01 SR-01000597691-1 C-55168 GTPL1443 NCGC00024467-01 UNII-H8B59H10OK component DDOQBQRIEWHWBT-GSVOUGTGSA-N (2R)-2-amino-4-phosphonobutanoic acid API0009835 CTK2I0929 M01255 SCHEMBL12648443 BN0083 FCH3604711 NCGC00015041-02 Tocris-0101 AC1LT3KN I04-1600 PDSP1_000361 ZINC1656225 (R)-2-Amino-4-phosphonobutanoic acid B6201 d(-)-2-amino-4-phosphonobutyric acid D-APB MolPort-004-956-473 SR-01000597691 78739-01-2 Butanoic acid, 2-amino-4-phosphono-, (2R)- [ Show all ]
Inchi Key	DDOQBQRIEWHWBT-GSVOUGTGSA-N
Inchi ID	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m1/s1
PubChem CID	1550579
ChEMBL	CHEMBL1319383
IUPHAR	1443
BindingDB	82006
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1030.0 nM	, None	BindingDB,ChEMBL

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