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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	UNII-QPE81T4KH0
Molecular formula	C23H32FN3O4
IUPAC name	6-fluoro-N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-3,3-dimethyl-2-oxoindole-1-carboxamide
Molecular weight	433.524
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.5
Synonyms	1H-Indole-1-carboxamide, 6-fluoro-2,3-dihydro-3,3-dimethyl-2-oxo-N-((1-((tetrahydro-4-hydroxy-2H-pyran-4-yl)methyl)-4-piperidinyl)methyl)- PF-03382792 DB12949 QPE81T4KH0 CHEMBL2179582 1400811-63-3 PF-03227077 BDBM50398588 D01ABX [ Show all ]
Inchi Key	AGMOFKKOVMRGAK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H32FN3O4/c1-22(2)18-4-3-17(24)13-19(18)27(20(22)28)21(29)25-14-16-5-9-26(10-6-16)15-23(30)7-11-31-12-8-23/h3-4,13,16,30H,5-12,14-15H2,1-2H3,(H,25,29)
PubChem CID	71451950
ChEMBL	CHEMBL2179582
IUPHAR	N/A
BindingDB	50398588
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	22.0 %	PMID22974325	ChEMBL
EC50	1.15 nM	PMID22974325	ChEMBL
EC50	1.2 nM	PMID22974325	BindingDB
EC50	1.5 nM	PMID22974325	BindingDB
EC50	1.52 nM	PMID22974325	ChEMBL
EC50	2.15 nM	PMID22974325	ChEMBL
EC50	2.2 nM	PMID22974325	BindingDB
Emax	37.0 %	PMID22974325	ChEMBL
Emax	46.0 %	PMID22974325	ChEMBL
Emax	63.0 %	PMID22974325	ChEMBL
Ki	3.9 nM	PMID22974325	BindingDB,ChEMBL

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