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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	CHEMBL3233865
Molecular formula	C30H32N2O4
IUPAC name	2-[1-[3-[(3-phenyl-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy]propyl]piperidin-4-yl]-1,3-benzoxazole
Molecular weight	484.596
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	5.6
Synonyms	BDBM50009383
Inchi Key	AGKFWTDVDBIRHM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H32N2O4/c1-2-9-22(10-3-1)29-28(34-26-13-6-7-14-27(26)35-29)21-33-20-8-17-32-18-15-23(16-19-32)30-31-24-11-4-5-12-25(24)36-30/h1-7,9-14,23,28-29H,8,15-21H2
PubChem CID	85471166
ChEMBL	CHEMBL3233865
IUPHAR	N/A
BindingDB	50009383
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.1 nM	PMID24618300	BindingDB,ChEMBL

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