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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	CHEMBL3560750
Molecular formula	C19H18BrFN2O3S
IUPAC name	(E)-1-[4-(3-bromophenyl)sulfonylpiperazin-1-yl]-3-(4-fluorophenyl)prop-2-en-1-one
Molecular weight	453.326
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.2
Synonyms	SCHEMBL16598704 SCHEMBL16598706 AKOS008554250 MLS-0472471.0001
Inchi Key	HQDSVBOPZYIHDN-RMKNXTFCSA-N
Inchi ID	InChI=1S/C19H18BrFN2O3S/c20-16-2-1-3-18(14-16)27(25,26)23-12-10-22(11-13-23)19(24)9-6-15-4-7-17(21)8-5-15/h1-9,14H,10-13H2/b9-6+
PubChem CID	26559312
ChEMBL	CHEMBL3560750
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	17.5 nM	PubChem BioAssay data set	ChEMBL

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