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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	CHEMBL209737
Molecular formula	C14H9ClN2O
IUPAC name	3-(4-chlorophenyl)imino-1H-indol-2-one
Molecular weight	256.689
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.3
Synonyms	ST45186303 (3E)-3-[(4-chlorophenyl)imino]-1,3-dihydro-2H-indol-2-one 3-(4-chloroanilino)indol-2-one AKOS000520092 CTK1F1604 MolPort-000-419-118 ZINC17858403 (E)-3-(4-chlorophenylimino)indolin-2-one 3-[(4-chlorophenyl)imino]-1H-indol-2-one BAS 00382583 HMS2853M17 Oprea1_004055 3-((4-CHLOROPHENYL)IMINO)INDOLIN-2-ONE 57644-24-3 MCULE-3557847305 SCHEMBL16444571 STK864175 (3Z)-3-[(4-chlorophenyl)imino]-1,3-dihydro-2H-indol-2-one 3-(4-Chlorophenylimino)indolin-2-one AKOS003804903 D0H0HM MolPort-008-323-784 1267671-95-3 3-[(4-chlorophenyl)imino]-2,3-dihydro-1H-indol-2-one BDBM50189599 KB-335076 Oprea1_763130 SMR000567636 3-(4-Chloro-phenylimino)-1,3-dihydro-indol-2-one AC1LE8U8 MLS001181903 Z57111178 (3Z)-3-[(4-chlorophenyl)imino]-2,3-dihydro-1H-indol-2-one 3-[(4-chlorophenyl)azamethylene]-1H-benzo[d]azolin-2-one AKOS034472301 DTXSID50350547 MS-6528 2H-Indol-2-one, 3-[(4-chlorophenyl)imino]-1,3-dihydro- CCG-236762 KS-00003P6K SBB062052 [ Show all ]
Inchi Key	CPOOLXVTWFEFNO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H9ClN2O/c15-9-5-7-10(8-6-9)16-13-11-3-1-2-4-12(11)17-14(13)18/h1-8H,(H,16,17,18)
PubChem CID	135411931
ChEMBL	CHEMBL209737
IUPHAR	N/A
BindingDB	50189599
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	850.0 nM	PMID16789730	BindingDB,ChEMBL

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