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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1B) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD5
Synonym	Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor D5 receptor D1beta dopamine receptor D(5) dopamine receptor D(1B) dopamine receptor [ Show all ]
Disease	Solid tumours Schizophrenia
Length	477
Amino acid sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProt	P21918
Protein Data Bank	N/A
GPCR-HGmod model	P21918
3D structure model	This predicted structure model is from GPCR-EXP P21918.
BioLiP	N/A
Therapeutic Target Database	T46828
ChEMBL	CHEMBL1850
IUPHAR	218
DrugBank	BE0000145, BE0004889

Ligand

Name	cid_654562
Molecular formula	C19H20N4O2S
IUPAC name	1'-acetyl-4-imino-11,13-dimethylspiro[3-oxa-8-thia-10-azatricyclo[7.4.0.02,7]trideca-1(9),2(7),10,12-tetraene-6,4'-piperidine]-5-carbonitrile
Molecular weight	368.455
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.6
Synonyms	BDBM48916 1-acetyl-2''-amino-7'',9''-dimethyl-3''-spiro[piperidine-4,4''-pyrano[3,4]thieno[1,3-b]pyridine]carbonitrile 2''-azanyl-1-ethanoyl-7'',9''-dimethyl-spiro[piperidine-4,4''-pyrano[3,4]thieno[1,3-b]pyridine]-3''-carbonitrile 1-acetyl-2''-amino-7'',9''-dimethyl-spiro[piperidine-4,4''-pyrano[3,4]thieno[1,3-b]pyridine]-3''-carbonitrile 1-acetyl-2''-amino-7'',9''-dimethylspiro[piperidine-4,4''-pyrano[3,4]thieno[1,3-b]pyridine]-3''-carbonitrile
Inchi Key	AGBGCBNXVPXCIQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20N4O2S/c1-10-8-11(2)22-18-14(10)15-16(26-18)19(13(9-20)17(21)25-15)4-6-23(7-5-19)12(3)24/h8,13,21H,4-7H2,1-3H3
PubChem CID	91896777
ChEMBL	N/A
IUPHAR	N/A
BindingDB	48916
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.0129 nM	N/A	BindingDB

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