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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	AC1OX4NE
Molecular formula	C20H18FN3O3S
IUPAC name	2-[4-[(E)-3-(4-fluorophenyl)prop-2-enoyl]piperazin-1-yl]sulfonylbenzonitrile
Molecular weight	399.44
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.2
Synonyms	2-[4-[(E)-3-(4-fluorophenyl)prop-2-enoyl]piperazin-1-yl]sulfonylbenzonitrile SCHEMBL16598740 CHEMBL3560541 SCHEMBL16598742 AKOS008442197 MLS-0472472.0001 [ Show all ]
Inchi Key	CWCUXMQIVLLWDM-JXMROGBWSA-N
Inchi ID	InChI=1S/C20H18FN3O3S/c21-18-8-5-16(6-9-18)7-10-20(25)23-11-13-24(14-12-23)28(26,27)19-4-2-1-3-17(19)15-22/h1-10H,11-14H2/b10-7+
PubChem CID	7942116
ChEMBL	CHEMBL3560541
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	48.2 nM	PubChem BioAssay data set	ChEMBL

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