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Name | Metabotropic glutamate receptor 3 |
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Species | Rattus norvegicus (Rat) |
Gene | Grm3 |
Synonym | mGluR3 mGlu3 receptor GPRC1C glutamate receptor |
Disease | N/A for non-human GPCRs |
Length | 879 |
Amino acid sequence | MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL |
UniProt | P31422 |
Protein Data Bank | 2e4u, 2e4v, 2e4w, 2e4x, 2e4y |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 2e4u. |
BioLiP | BL0086116,BL0086117, BL0086120,BL0086121, BL0086118,BL0086119, BL0086114,BL0086115, BL0086112,BL0086113 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3067 |
IUPHAR | 291 |
DrugBank | N/A |
Name | CHEMBL3617616 |
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Molecular formula | C19H16ClFN4O2 |
IUPAC name | (7R)-5-(4-chlorophenyl)-2-[(5-fluoropyridin-2-yl)oxymethyl]-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one |
Molecular weight | 386.811 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 3.2 |
Synonyms | (7R)-2-(5-Fluoro-2-pyridyloxy)methyl-5-(4-chlorophenyl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-one BDBM50122276 |
Inchi Key | BGUIRBNHGKTOPB-GFCCVEGCSA-N |
Inchi ID | InChI=1S/C19H16ClFN4O2/c1-12-10-24(16-5-2-13(20)3-6-16)19(26)17-8-15(23-25(12)17)11-27-18-7-4-14(21)9-22-18/h2-9,12H,10-11H2,1H3/t12-/m1/s1 |
PubChem CID | 122190393 |
ChEMBL | CHEMBL3617616 |
IUPHAR | N/A |
BindingDB | 50122276 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 2.17 % | PMID26335039 | ChEMBL |
IC50 | 194.98 nM | PMID26335039 | ChEMBL |
IC50 | 195.0 nM | PMID26335039 | BindingDB |
IC50 | 197.0 nM | PMID26335039 | BindingDB,ChEMBL |
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