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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	naphazoline
Molecular formula	C14H14N2
IUPAC name	2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
Molecular weight	210.28
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.1
Synonyms	2-(1-Naphthalenylmethyl)-2-imidazoline Nadaplatin 2-(Naphthyl-(1')-methyl)imidazolin [German] 550-99-2 (mono-hydrochloride) Naphthizine AC1L1I5Y Prestwick1_000046 BDBM50001922 SPBio_001008 C-23907 STK300042 Ciba 2020/R DivK1c_000456 IDI1_000456 KBio2_006591 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole Nafazolin (TN) 2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; hydrochloride Naphazoline [INN:BAN] A840596 NCGC00016506-03 AKOS000295230 Privine (Salt/Mix) BRD-K77641333-003-15-6 Spectrum3_000513 CCG-250339 Z56762888 CNIIGCLFLJGOGP-UHFFFAOYSA-N FT-0725973 K490 KBioSS_001455 MCULE-9097339235 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole Nafazoline 5-23-08-00293 (Beilstein Handbook Reference) Naphazolinum [Latin] AB00053505_13 NINDS_000456 Antan SBI-0051454.P003 BSPBio_000171 Spectrum_000975 HMS1394P03 KBio2_001455 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)- 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole NAFAZAIR 2-(naphthylmethyl)-2-imidazoline Naphazoline (INN) 550N992 NCGC00016506-01 AJ-11616 Prestwick2_000046 BPBio1_000189 SPBio_002092 C14H14N2 T8212 cid_11079 EINECS 212-641-5 IMI033 KBio3_001565 L000878 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole # Nafazolina 2-[(naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole Naphazolinum AB00053505-11 NCGC00016506-04 alpha-Naphthylmethyl imidazoline Rhinazine BRD-K77641333-003-25-5 Spectrum4_000068 CHEBI:93363 ZINC119717 D08253 GTPL5509 KB-224262 MolPort-001-641-043 2-(Naphthyl-(1')-methyl)imidazolin Nafazoline [Spanish] Naphcon AB00053505_14 Prestwick0_000046 BBL012612 SCHEMBL34532 BSPBio_002065 ST45061546 CHEMBL761 DB06711 HMS2090D15 KBio2_004023 2-(.alpha.-Naphthylmethyl)-imidazoline 2-(1-Naphthylmethyl)-2-imidazoline Nafazolin 2-Imidazoline, 2-(1-naphthylmethyl)- Naphazoline Monohydrochloride 835-31-4 NCGC00016506-02 AK-968/41090774 Prestwick3_000046 BRD-K77641333-003-05-7 Spectrum2_001054 CC-32429 UNII-H231GF11BV Clearine Enamine_000333 Imidin KBioGR_000595 LS-79666 2-(alpha-Naphthylmethyl)-imidazoline Nafazolina [DCIT] 4,5-Dihydro-2-(1-naphthylmethyl)imidazole Naphazolinum [INN-Latin] AB00053505-12 NCGC00016506-05 AN-47765 Sanorin (Salt/Mix) BRN 0151864 Spectrum5_001424 CHEMBL1706 D0O6IZ H231GF11BV KBio1_000456 .alpha.-Naphthylmethyl imidazoline [ Show all ]
Inchi Key	CNIIGCLFLJGOGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
PubChem CID	4436
ChEMBL	CHEMBL761
IUPHAR	N/A
BindingDB	50001922
DrugBank	DB06711
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	54.95 nM	PMID25648685	ChEMBL
EC50	55.0 nM	PMID25648685	BindingDB
Emax	55.0 %	PMID25648685	ChEMBL
Emax	102.0 %	PMID25648685	ChEMBL
Ki	2.291 nM	PMID25648685	ChEMBL
Ki	2.3 nM	PMID25648685	BindingDB
Ki	407.38 nM	PMID9605427	BindingDB
Ki	407.38 nM	PMID9605427	PDSP

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