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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-2 adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adrb2
Synonym	beta2-adrenoceptor Beta-2 adrenoreceptor Beta-2 adrenoceptor beta-2 adrenergic receptor beta 2-AR B2AR adrenoceptor beta 2, surface adrenergic receptor ADRBR ADRB2R Adrb-2 Gpcr7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	418
Amino acid sequence	MEPHGNDSDFLLAPNGSRAPGHDITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKQAIDCYAKETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGRSGHGLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEQSAYQLGQEKENELLCEEAPGMEGFVNCQGTVPSLSIDSQGRNCNTNDSPL
UniProt	P10608
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3754
IUPHAR	29
DrugBank	N/A

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Levopraid BPBio1_000463 LP01050 Calmoflorine Miradol CHEMBL26 N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Desmenat Dresent (+/-)-Sulpiride Enimon GTPL5501 5-22-08-00105 (Beilstein Handbook Reference) HMS3372O01 AKOS004912732 Isnamide SPBio_002132 Sulperide Sulpiride, British Pharmacopoeia (BP) Reference Standard Sulpitil Tox21_501050 NCGC00015966-06 NCGC00261735-01 Omiryl Prestwick_431 Restful KBio1_000278 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpiride [INN] BRD-A55272860-001-04-7 Magnetic resonance imaging sulpiride CCRIS 4248 MLS000069434 CTK8F2082 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Dobren (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide DSSTox_RID_80050 (plusmn)-sulpiride EU-0101050 15676-16-1 HMS2095K13 AB0105833 HMS3712K13 AN-1019 S0501 SR-01000075402-2 Sulpirida [INN-Spanish] SULPIRIDE,(+) Sulpyrid Zemorcon NCGC00024852-02 Norestran Ozoderpin Pyrikappl BDBM11638 L-Sulpiride Biomol-NT_000162 Lisopiride BSPBio_000211 Meresa CHEBI:32168 N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Dogmatyl (TN) (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Eglonyl (RS)-(A+/-)-Sulpiride Fidelan 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide HMS3266P12 AC1L1K62 I06-0054 Sernevin Stamonevrol Sulpiride 1.0 mg/ml in Methanol Sulpiridum Synedil NCGC00015966-04 NCGC00024852-05 o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- Prestwick2_000056 R.D. 1403 J10067 Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpirida BPBio1_001255 LS-20058 CAS-15676-16-1 Mirbanil Coolspan N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide DivK1c_000278 ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide DSSTox_CID_22574 (.+/-.)-Sulpiride Equilid 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Guastil HMS3393A08 Alimoral Splotin Sulpirid Sulpiride, European Pharmacopoeia (EP) Reference Standard Sulpor Valirem NCGC00015966-07 Neogama Omperan Psicocen RV-12309 KS-00000YBQ BGRJTUBHPOOWDU-UHFFFAOYSA-N Levosulpiridum BRD-A55272860-001-08-8 Mariastel CCRIS-4248 MLS001306443 D01226 Dogmatil (+-)-sulpiride DTXSID1042574 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eusulpid 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide HMS2231K07 Abilit HMS500N20 BCP04500 s4655 SR-01000075402-3 SULPIRIDE,(-) Suprium N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide NCGC00024852-03 Normum Prestwick0_000056 Pyrkappl Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- L000579 BPBio1_000233 Lopac0_001050 C15H23N3O4S MFCD00055061 N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide DB00391 Dolmatil (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide EINECS 239-753-7 (y)-Sulpiride FT-0652244 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide HMS3371P16 Aiglonyl IDI1_000278 SMR000038923 STK368596 Sulpiride [USAN:INN:BAN:JAN] Sulpiridum [INN-Latin] Tox21_302205 NCGC00015966-05 NCGC00255813-01 o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- Prestwick3_000056 RD 1403 KB-295026 Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Levosulpirida [INN-Spanish] BRD-A55272860-001-03-9 LS-20059 CCG-205127 Misulvan CS-4534 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide dl-sulpiride ( inverted question mark)-Sulpiride DSSTox_GSID_42574 (?)-Sulpiride EU-0001755 HMS1568K13 676S161 HMS3651G12 AN-1017 SR-01000075402 Sulpirida Sulpiride, SLP Sulpride Z84655412 NCGC00015966-08 NINDS_000278 Oprea1_602476 PubChem17241 S 8010 BCP13871 Kylistro Biomol-NT_000037 Levosulpiridum [INN-Latin] BRN 0494008 MCULE-7506797476 Championyl MolPort-002-070-475 Darleton Dogmatyl (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eglonil (RS)-(+/-)-sulpiride Fardalan 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide HMS3263A22 AC-12181 HY-B1019 SCHEMBL8421 SR-01000075402-6 Sulpiride (JP17/USAN/INN) Sulpiride-R Sursumid NCGC00015966-03 NCGC00024852-04 Nufarol Prestwick1_000056 R. D. 1403 [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID2869639	BindingDB

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