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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-2 adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adrb2
Synonym	beta2-adrenoceptor Beta-2 adrenoreceptor Beta-2 adrenoceptor beta-2 adrenergic receptor beta 2-AR B2AR adrenoceptor beta 2, surface adrenergic receptor ADRBR ADRB2R Adrb-2 Gpcr7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	418
Amino acid sequence	MEPHGNDSDFLLAPNGSRAPGHDITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKQAIDCYAKETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGRSGHGLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEQSAYQLGQEKENELLCEEAPGMEGFVNCQGTVPSLSIDSQGRNCNTNDSPL
UniProt	P10608
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3754
IUPHAR	29
DrugBank	N/A

Ligand

Name	sulpiride
Molecular formula	C15H23N3O4S
IUPAC name	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular weight	341.426
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	0.6
Synonyms	HMS2231K07 o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl- Abilit HMS500N20 Prestwick2_000056 BCP04500 KS-00000YBQ R.D. 1403 BGRJTUBHPOOWDU-UHFFFAOYSA-N Levosulpiridum Sernevin BRD-A55272860-001-08-8 Mariastel Stamonevrol CCRIS-4248 MLS001306443 Sulpiride 1.0 mg/ml in Methanol D01226 Sulpiridum Dogmatil (+-)-sulpiride Synedil DTXSID1042574 NCGC00015966-04 (RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Eusulpid NCGC00024852-05 5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide 5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide HMS3371P16 Omperan Aiglonyl IDI1_000278 Psicocen Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy- L000579 RV-12309 BPBio1_000233 Lopac0_001050 Splotin C15H23N3O4S MFCD00055061 Sulpirid N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide Sulpiride, European Pharmacopoeia (EP) Reference Standard DB00391 Sulpor Dolmatil (+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide Valirem EINECS 239-753-7 NCGC00015966-07 (y)-Sulpiride FT-0652244 Neogama HMS1568K13 Normum 676S161 HMS3651G12 Prestwick0_000056 AN-1017 KB-295026 Pyrkappl Benzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoyl-, S-(-)- Levosulpirida [INN-Spanish] s4655 BRD-A55272860-001-03-9 LS-20059 SR-01000075402-3 CCG-205127 Misulvan CS-4534 N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide SULPIRIDE,(-) dl-sulpiride ( inverted question mark)-Sulpiride Suprium DSSTox_GSID_42574 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide (?)-Sulpiride EU-0001755 NCGC00024852-03 HMS3263A22 o-ANISAMIDE, N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-SULFAMOYL-, (S)-(-)- AC-12181 HY-B1019 Prestwick3_000056 BCP13871 Kylistro RD 1403 Biomol-NT_000037 Levosulpiridum [INN-Latin] SMR000038923 BRN 0494008 MCULE-7506797476 STK368596 Championyl MolPort-002-070-475 Sulpiride [USAN:INN:BAN:JAN] Darleton Sulpiridum [INN-Latin] Dogmatyl (+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Tox21_302205 Eglonil NCGC00015966-05 (RS)-(+/-)-sulpiride Fardalan NCGC00255813-01 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide NINDS_000278 5-22-08-00105 (Beilstein Handbook Reference) HMS3372O01 Oprea1_602476 AKOS004912732 Isnamide PubChem17241 Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- Levopraid S 8010 BPBio1_000463 LP01050 SR-01000075402 Calmoflorine Miradol Sulpirida CHEMBL26 N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Sulpiride, SLP Desmenat Sulpride Dresent (+/-)-Sulpiride Z84655412 Enimon NCGC00015966-08 GTPL5501 HMS2095K13 Nufarol AB0105833 HMS3712K13 Prestwick1_000056 AN-1019 KBio1_000278 R. D. 1403 Benzamide,5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpiride [INN] SCHEMBL8421 BRD-A55272860-001-04-7 Magnetic resonance imaging sulpiride SR-01000075402-6 CCRIS 4248 MLS000069434 Sulpiride (JP17/USAN/INN) CTK8F2082 N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Sulpiride-R Dobren (+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide Sursumid DSSTox_RID_80050 NCGC00015966-03 (plusmn)-sulpiride EU-0101050 NCGC00024852-04 15676-16-1 5-(Aminosulfonyl)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-2-methoxy- benzamide HMS3266P12 Omiryl AC1L1K62 I06-0054 Prestwick_431 BDBM11638 L-Sulpiride Restful Biomol-NT_000162 Lisopiride SPBio_002132 BSPBio_000211 Meresa Sulperide CHEBI:32168 N-(((S)-1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide Sulpiride, British Pharmacopoeia (BP) Reference Standard Sulpitil Dogmatyl (TN) (+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide Tox21_501050 Eglonyl NCGC00015966-06 (RS)-(A+/-)-Sulpiride Fidelan NCGC00261735-01 Norestran HMS3393A08 Ozoderpin Alimoral J10067 Pyrikappl Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy- Levosulpirida S0501 BPBio1_001255 LS-20058 SR-01000075402-2 CAS-15676-16-1 Mirbanil Sulpirida [INN-Spanish] Coolspan N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide SULPIRIDE,(+) DivK1c_000278 ( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide Sulpyrid DSSTox_CID_22574 (.+/-.)-Sulpiride Zemorcon Equilid NCGC00024852-02 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine Guastil [ Show all ]
Inchi Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
PubChem CID	5355
ChEMBL	CHEMBL26
IUPHAR	5501
BindingDB	11638
DrugBank	DB00391
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID2869639	BindingDB

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