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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL3692841
Molecular formula	C17H15NO3S
IUPAC name	8-(benzenesulfonyl)-1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridine
Molecular weight	313.371
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.6
Synonyms	8-(Phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine US9067949, 28 AGJMBLMVRSXPOC-UHFFFAOYSA-N BDBM166171 SCHEMBL10322900
Inchi Key	AGJMBLMVRSXPOC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H15NO3S/c19-22(20,12-4-2-1-3-5-12)13-6-7-16-14(10-13)15-11-18-9-8-17(15)21-16/h1-7,10,18H,8-9,11H2
PubChem CID	57414390
ChEMBL	CHEMBL3692841
IUPHAR	N/A
BindingDB	166171
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	19.0 nM	, None	BindingDB,ChEMBL

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