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Name | C-C chemokine receptor type 3 |
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Species | Homo sapiens (Human) |
Gene | CCR3 |
Synonym | MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 [ Show all ] |
Disease | Allergic asthma Allergic rhinitis Asthma |
Length | 355 |
Amino acid sequence | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF |
UniProt | P51677 |
Protein Data Bank | N/A |
GPCR-HGmod model | P51677 |
3D structure model | This predicted structure model is from GPCR-EXP P51677. |
BioLiP | N/A |
Therapeutic Target Database | T02752, T85228 |
ChEMBL | CHEMBL3473 |
IUPHAR | 60 |
DrugBank | N/A |
Name | CHEMBL3355963 |
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Molecular formula | C32H35F2N3O2S |
IUPAC name | ethyl 2-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-4-carboxylate |
Molecular weight | 563.708 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 7.3 |
Synonyms | BDBM50041089 |
Inchi Key | VJUTWTGDFJIQRL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C32H35F2N3O2S/c1-3-28-31(22-13-17-36(18-14-22)16-5-19-40-26-9-6-24(33)7-10-26)27-11-8-25(34)21-29(27)37(28)30-20-23(12-15-35-30)32(38)39-4-2/h6-12,15,20-22H,3-5,13-14,16-19H2,1-2H3 |
PubChem CID | 118721203 |
ChEMBL | CHEMBL3355963 |
IUPHAR | N/A |
BindingDB | 50041089 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 98.0 nM | PMID25497216 | BindingDB,ChEMBL |
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