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Name | C-C chemokine receptor type 3 |
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Species | Rattus norvegicus (Rat) |
Gene | Ccr3 |
Synonym | CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 359 |
Amino acid sequence | MASNEEELKTVVETFETTPYEYEWAPPCEKVSIRELGSWLLPPLYSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNEWGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVLALRARTVTFATITSIITWGFAVLAALPEFIFHESQDNFGDLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFLETSCQQSIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLPGEKLERTSSVSPSTGEQEISVVF |
UniProt | O54814 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3928 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL3355960 |
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Molecular formula | C30H31F2N3O2S |
IUPAC name | 6-[2-ethyl-6-fluoro-3-[1-[3-(4-fluorophenyl)sulfanylpropyl]piperidin-4-yl]indol-1-yl]pyridine-2-carboxylic acid |
Molecular weight | 535.654 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 4.7 |
Synonyms | BDBM50041198 SCHEMBL2143252 |
Inchi Key | RKONWZSIRONAFM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C30H31F2N3O2S/c1-2-26-29(20-13-16-34(17-14-20)15-4-18-38-23-10-7-21(31)8-11-23)24-12-9-22(32)19-27(24)35(26)28-6-3-5-25(33-28)30(36)37/h3,5-12,19-20H,2,4,13-18H2,1H3,(H,36,37) |
PubChem CID | 25024650 |
ChEMBL | CHEMBL3355960 |
IUPHAR | N/A |
BindingDB | 50041198 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1700.0 nM | PMID25497216 | BindingDB,ChEMBL |
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