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Name | C-C chemokine receptor type 3 |
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Species | Homo sapiens (Human) |
Gene | CCR3 |
Synonym | MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 [ Show all ] |
Disease | Allergic asthma Allergic rhinitis Asthma |
Length | 355 |
Amino acid sequence | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF |
UniProt | P51677 |
Protein Data Bank | N/A |
GPCR-HGmod model | P51677 |
3D structure model | This predicted structure model is from GPCR-EXP P51677. |
BioLiP | N/A |
Therapeutic Target Database | T02752, T85228 |
ChEMBL | CHEMBL3473 |
IUPHAR | 60 |
DrugBank | N/A |
Name | CHEMBL3355935 |
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Molecular formula | C24H29FN2OS |
IUPAC name | 4-[3-[4-(2-ethyl-6-fluoro-1H-indol-3-yl)piperidin-1-yl]propylsulfanyl]phenol |
Molecular weight | 412.567 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 5.8 |
Synonyms | BDBM50041163 |
Inchi Key | QULTXLKAKCQMRD-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H29FN2OS/c1-2-22-24(21-9-4-18(25)16-23(21)26-22)17-10-13-27(14-11-17)12-3-15-29-20-7-5-19(28)6-8-20/h4-9,16-17,26,28H,2-3,10-15H2,1H3 |
PubChem CID | 118721186 |
ChEMBL | CHEMBL3355935 |
IUPHAR | N/A |
BindingDB | 50041163 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 78.0 nM | PMID25497216 | BindingDB,ChEMBL |
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