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Name | Sphingosine 1-phosphate receptor 4 |
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Species | Homo sapiens (Human) |
Gene | S1PR4 |
Synonym | S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 [ Show all ] |
Disease | N/A |
Length | 384 |
Amino acid sequence | MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI |
UniProt | O95977 |
Protein Data Bank | N/A |
GPCR-HGmod model | O95977 |
3D structure model | This predicted structure model is from GPCR-EXP O95977. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3230 |
IUPHAR | 278 |
DrugBank | N/A |
Name | SR-01000698447 |
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Molecular formula | C23H24ClN3O3 |
IUPAC name | [1-(4-ethylanilino)-1-oxopropan-2-yl] 1-benzyl-5-chloro-3-methylpyrazole-4-carboxylate |
Molecular weight | 425.913 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 5.1 |
Synonyms | 1-benzyl-5-chloro-3-methyl-pyrazole-4-carboxylic acid [2-(4-ethylanilino)-2-keto-1-methyl-ethyl] ester HMS2608C06 Z25456736 AKOS033941815 MolPort-005-863-021 [ Show all ] |
Inchi Key | CMESBGDQHPKECY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H24ClN3O3/c1-4-17-10-12-19(13-11-17)25-22(28)16(3)30-23(29)20-15(2)26-27(21(20)24)14-18-8-6-5-7-9-18/h5-13,16H,4,14H2,1-3H3,(H,25,28) |
PubChem CID | 3324089 |
ChEMBL | CHEMBL1384963 |
IUPHAR | N/A |
BindingDB | 79461 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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EC50 | <50000.0 nM | , PubChem BioAssay data set | BindingDB,ChEMBL |
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