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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	SMR000001597
Molecular formula	C19H16N4O3S
IUPAC name	2-[[5-(benzimidazol-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone
Molecular weight	380.422
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.1
Synonyms	2-[[5-(1-benzimidazolylmethyl)-1,3,4-oxadiazol-2-yl]thio]-1-(4-methoxyphenyl)ethanone SR-01000610545-4 HMS2381K18 ASN 01915842 MLS002535810 2-[[5-(benzimidazol-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone CHEMBL1557584 SR-01000610545 ZINC877641 AC1LDJJR MCULE-8436093380 2-(5-Benzoimidazol-1-ylmethyl-[1,3,4]oxadiazol-2-ylsulfanyl)-1-(4-methoxy-phenyl)-ethanone BDBM97056 REGID_for_CID_649098 2-[[5-(benzimidazol-1-ylmethyl)-1,3,4-oxadiazol-2-yl]thio]-1-(4-methoxyphenyl)ethanone cid_649098 SR-01000610545-3 AKOS000722908 MLS000070323 [ Show all ]
Inchi Key	CLSFRRNGXVOEMO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H16N4O3S/c1-25-14-8-6-13(7-9-14)17(24)11-27-19-22-21-18(26-19)10-23-12-20-15-4-2-3-5-16(15)23/h2-9,12H,10-11H2,1H3
PubChem CID	649098
ChEMBL	CHEMBL1557584
IUPHAR	N/A
BindingDB	97056
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	890.66 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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