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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	CHEMBL3314353
Molecular formula	C22H26N4O
IUPAC name	[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-(1,5-dimethylpyrrolo[2,3-c]pyridin-2-yl)methanone
Molecular weight	362.477
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.5
Synonyms	BDBM50045844
Inchi Key	JEWNWDVCPPSWTG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26N4O/c1-15-9-19-11-20(25(4)21(19)12-23-15)22(27)26-8-7-17-10-16(13-24(2)3)5-6-18(17)14-26/h5-6,9-12H,7-8,13-14H2,1-4H3
PubChem CID	118707554
ChEMBL	CHEMBL3314353
IUPHAR	N/A
BindingDB	50045844
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	18900.0 nM	PMID24937104	BindingDB,ChEMBL

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