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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide FF receptor 1
Species	Homo sapiens (Human)
Gene	NPFFR1
Synonym	GnIH-R G protein-coupled receptor 147 OT7T022 NPFF1R1 NPFF1 receptor NPFF1 G-protein coupled receptor 147 GPR147 GnIH-R/RFRP-3 RFamide-related peptide receptor OT7T022 [ Show all ]
Disease	N/A
Length	430
Amino acid sequence	MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
UniProt	Q9GZQ6
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZQ6
3D structure model	This predicted structure model is from GPCR-EXP Q9GZQ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5951
IUPHAR	300
DrugBank	N/A

Ligand

Name	CHEMBL3361424
Molecular formula	C24H33N5O
IUPAC name	N-[[1-benzyl-4-(2-phenylethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamide
Molecular weight	407.562
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.6
Synonyms	BDBM50029122
Inchi Key	ISCAWZRRKXBDFH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H33N5O/c25-23(26)27-17-22(30)28-19-24(12-11-20-7-3-1-4-8-20)13-15-29(16-14-24)18-21-9-5-2-6-10-21/h1-10H,11-19H2,(H,28,30)(H4,25,26,27)
PubChem CID	118724985
ChEMBL	CHEMBL3361424
IUPHAR	N/A
BindingDB	50029122
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	151.0 nM	PMID25268943	BindingDB,ChEMBL

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