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GPCR

NameD(1A) dopamine receptor
SpeciesSus scrofa (Pig)
GeneDRD1
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLGKTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProtP50130
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5067
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3318835
Molecular formulaC50H56Cl2F2N2O6
IUPAC namebis[4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] octanedioate
Molecular weight889.903
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP10.2
SynonymsBDBM50053380
Inchi KeyDPDUJCCKQWFBBQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C50H56Cl2F2N2O6/c51-41-19-15-39(16-20-41)49(27-33-55(34-28-49)31-5-7-45(57)37-11-23-43(53)24-12-37)61-47(59)9-3-1-2-4-10-48(60)62-50(40-17-21-42(52)22-18-40)29-35-56(36-30-50)32-6-8-46(58)38-13-25-44(54)26-14-38/h11-26H,1-10,27-36H2
PubChem CID118709163
ChEMBLCHEMBL3318835
IUPHARN/A
BindingDB50053380
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki920.0 nMPMID25047579BindingDB,ChEMBL

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