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Name | C-C chemokine receptor type 3 |
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Species | Rattus norvegicus (Rat) |
Gene | Ccr3 |
Synonym | CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 359 |
Amino acid sequence | MASNEEELKTVVETFETTPYEYEWAPPCEKVSIRELGSWLLPPLYSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNEWGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVLALRARTVTFATITSIITWGFAVLAALPEFIFHESQDNFGDLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFLETSCQQSIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLPGEKLERTSSVSPSTGEQEISVVF |
UniProt | O54814 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3928 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL3355965 |
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Molecular formula | C34H38Cl2FN5O3 |
IUPAC name | 6-[3-[1-[(3R)-4-(3,4-dichlorophenyl)-3-(ethylcarbamoylamino)butyl]piperidin-4-yl]-2-ethyl-6-fluoroindol-1-yl]pyridine-3-carboxylic acid |
Molecular weight | 654.608 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | 4.8 |
Synonyms | BDBM50041091 |
Inchi Key | CRQFSPXWIUARST-VWLOTQADSA-N |
Inchi ID | InChI=1S/C34H38Cl2FN5O3/c1-3-29-32(26-8-7-24(37)19-30(26)42(29)31-10-6-23(20-39-31)33(43)44)22-11-14-41(15-12-22)16-13-25(40-34(45)38-4-2)17-21-5-9-27(35)28(36)18-21/h5-10,18-20,22,25H,3-4,11-17H2,1-2H3,(H,43,44)(H2,38,40,45)/t25-/m0/s1 |
PubChem CID | 118721205 |
ChEMBL | CHEMBL3355965 |
IUPHAR | N/A |
BindingDB | 50041091 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 3500.0 nM | PMID25497216 | BindingDB,ChEMBL |
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