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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL263488
Molecular formula	C81H106ClN15O13
IUPAC name	(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-(propanoylamino)phenyl]propanoyl]amino]-3-[4-(propanoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(1R)-1-aminoethyl]pyrrolidine-2-carboxamide
Molecular weight	1533.28
Hydrogen bond acceptor	16
Hydrogen bond donor	14
XlogP	6.5
Synonyms	N/A
Inchi Key	BWPCYKIWDAEZES-OUPPYNCOSA-N
Inchi ID	InChI=1S/C81H106ClN15O13/c1-9-71(100)88-60-32-25-53(26-33-60)42-66(75(104)91-63(39-48(3)4)73(102)90-62(20-13-14-37-85-49(5)6)81(110)97-38-16-21-70(97)80(109)86-50(7)83)93-77(106)67(43-54-27-34-61(35-28-54)89-72(101)10-2)95-79(108)69(47-98)96-78(107)68(45-56-17-15-36-84-46-56)94-76(105)65(41-52-23-30-59(82)31-24-52)92-74(103)64(87-51(8)99)44-55-22-29-57-18-11-12-19-58(57)40-55/h11-12,15,17-19,22-36,40,46,48-50,62-70,85,98H,9-10,13-14,16,20-21,37-39,41-45,47,83H2,1-8H3,(H,86,109)(H,87,99)(H,88,100)(H,89,101)(H,90,102)(H,91,104)(H,92,103)(H,93,106)(H,94,105)(H,95,108)(H,96,107)/t50-,62+,63+,64-,65-,66-,67+,68-,69+,70+/m1/s1
PubChem CID	44323286
ChEMBL	CHEMBL263488
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Duration of action	72.0 hr	PMID7629804	ChEMBL
No. of rats ovulated	0.0 -	PMID7629804	ChEMBL

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