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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	4-Methoxycinnamic acid
Molecular formula	C10H10O3
IUPAC name	(E)-3-(4-methoxyphenyl)prop-2-enoic acid
Molecular weight	178.187
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.8
Synonyms	NCGC00159448-02 4-Methoxy-(2E)-cinnamic acid O-Methyl-p-coumarate 7340-42-3 (hydrochloride salt) p-methoxycinnamate AC1Q5RAR PubChem8248 AKOS B000181 SCHEMBL58699 AS01561 TR-049560 CHEBI:48541 W-104154 DSSTox_RID_81310 (2E)-3-(4-METHOXYPHENYL)ACRYLIC ACID HY-N1387 (E)-4-METHOXYCINNAMIC ACID M0576 3-(4-Methoxy-phenyl)-acrylic acid 3-(4-methoxyphenyl)acrylic acid NSC 5303 OTAVA-BB 0123400502 943-89-5 p-Methoxycinnamic acid, predominantly trans AFDXODALSZRGIH-QPJJXVBHSA-N RTR-025896 AKOS000118882 ST2410363 BCP21420 trans-4-methoxy-cinnamic acid Cinnamic acid, 4-methoxy- EINECS 212-594-0 (E)-3-(4-methoxyphenyl)-2-propenoic acid KB-72675 0C546A89-9721-4B4E-89EE-7EC28A9A3391 METHOXYCINNAMIC ACID,4- MolPort-000-655-960 4-Methoxy cinnamate NSC5303 4-Methoxycinnamic acid, predominantly trans, 99% P-Methoxy ciannamic acid AC-10371 PMCA AK-98686 SC-50019 ARONIS000351 Tox21_111674 bmse010212 UNII-6G4ML8401A DSSTox_CID_26059 HMS1783A08 (E)-3-(4-Methoxyphenyl)acrylic acid LS-123672 2-Propenoic acid, 3-(4-methoxyphenyl)-, (E)- NCGC00159448-03 4-Methoxybenzeneacrylic acid O-Methyl-p-coumaric acid 830-09-1 P-METHOXYCINNAMIC ACID AE-641/00135031 RARECHEM BK HC T257 AKOS BBB/225 SMR000112200 AZ0001-0155 trans-2-Propenoic acid, 3-(4-methoxyphenyl)- ZINC77999 DTXSID1046059 (2E)-3-(4-methoxyphenyl)prop-2-enoic acid I04-9543 (E)-p-Methoxy-cinnamic acid MCULE-6993960877 3-(4-methoxyphenyl)-2-Propenoate 3-(4-methoxyphenyl)prop-2-enoic acid NSC-5303 4-Methoxycinnamic acid, >=98.0% (GC) p-MCA A837404 para-methoxycinnamate AI3-23399 RTR-029508 ALBB-011726 STK005095 BDBM50146453 trans-4-Methoxycinnamate Cinnamic acid, p-methoxy- EINECS 213-405-4 (E)-3-(4-methoxyphenyl)-acrylic acid LABOTEST-BB LT00108121 2-Propenoic acid, 3-(4-methoxyphenyl)- MFCD00004398 MP-2212 4-Methoxy cinnamic acid NSC623437 6G4ML8401A p-methoxy-cinnamic acid AC1LF8QH PS-5777 AKOS A1230-2778 SC-77648 ART-CHEM-BB B000181 TR-029508 CAS-943-89-5 W-100196 DSSTox_GSID_46059 (2E)-3-(4-Methoxyphenyl)-2-propenoic acid # HMS2267B19 (E)-3-(4-methoxyphenyl)prop-2-enoic acid LS11390 3-(4-Methoxy-phenyl)-acrylate NCGC00159448-04 4-Methoxycinnamate O-Methyl-p-cumaric Acid 830M091 p-Methoxycinnamic acid, 99%, predominantly trans AFDXODALSZRGIH-QPJJXVBHSA- RP17443 AKOS BBS-00000769 ST098720 BBL012085 trans-3-(4-Methoxyphenyl)acrylic acid CHEMBL95770 EBD2197791 (E)-3-(4-Methoxy-phenyl)-acrylic acid InChI=1/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+ (E)-p-Methoxycinnamic acid METHOXYCINNAMIC ACID, PARA 3-(4-Methoxyphenyl)-2-propenoic acid 30-09-1 NSC-623437 4-Methoxycinnamic acid, predominantly trans P-Methoxy ciannamate AB1003581 para-methoxycinnamic acid AJ-10423 SBB005717 AN-20523 TIMTEC-BB SBB005717 Bernel hydro trans-4-Methoxycinnamic acid CS-0016807 F1638-0067 (E)-3-(4-Methoxyphenyl)acrylate LABOTEST-BB LT03333631 2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- MLS002473129 [ Show all ]
Inchi Key	AFDXODALSZRGIH-QPJJXVBHSA-N
Inchi ID	InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+
PubChem CID	699414
ChEMBL	CHEMBL95770
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	0.0 %	PMID21167710	ChEMBL

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