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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanocortin receptor 4
Species	Homo sapiens (Human)
Gene	MC4R
Synonym	MC4-R MC4 receptor
Disease	Obesity; Sexual dysfunction Obesity; Diabetes Obesity Metabolic disorders Sexual dysfunction Sexual dysfunction; Obesity Female sexual dysfunction Erectile dysfunction Cachexia Anorexia nervosa cachexia [ Show all ]
Length	332
Amino acid sequence	MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
UniProt	P32245
Protein Data Bank	N/A
GPCR-HGmod model	P32245
3D structure model	This predicted structure model is from GPCR-EXP P32245.
BioLiP	N/A
Therapeutic Target Database	T72458
ChEMBL	CHEMBL259
IUPHAR	285
DrugBank	N/A

Ligand

Name	CHEMBL2035935
Molecular formula	C20H23N3O2
IUPAC name	(3S,4S)-3-N,4-N-dibenzylpyrrolidine-3,4-dicarboxamide
Molecular weight	337.423
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.1
Synonyms	BDBM50385156
Inchi Key	ACFLFTASFIWDPS-QZTJIDSGSA-N
Inchi ID	InChI=1S/C20H23N3O2/c24-19(22-11-15-7-3-1-4-8-15)17-13-21-14-18(17)20(25)23-12-16-9-5-2-6-10-16/h1-10,17-18,21H,11-14H2,(H,22,24)(H,23,25)/t17-,18-/m1/s1
PubChem CID	70685980
ChEMBL	CHEMBL2035935
IUPHAR	N/A
BindingDB	50385156
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	900.0 nM	PMID22551631	BindingDB,ChEMBL

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