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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Somatostatin receptor type 2
Species	Homo sapiens (Human)
Gene	SSTR2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	Acromegaly Lung cancer Neuroendocrine cancer
Length	369
Amino acid sequence	MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30874
Protein Data Bank	N/A
GPCR-HGmod model	P30874
3D structure model	This predicted structure model is from GPCR-EXP P30874.
BioLiP	N/A
Therapeutic Target Database	T53024
ChEMBL	CHEMBL1804
IUPHAR	356
DrugBank	BE0003528

Ligand

Name	CHEMBL466609
Molecular formula	C34H39N5O3
IUPAC name	(2S)-6-amino-2-[(4R)-3-oxo-4-[(2-phenylacetyl)amino]-1,4,5,10-tetrahydroazepino[3,4-b]indol-2-yl]-N-[(1S)-1-phenylethyl]hexanamide
Molecular weight	565.718
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	3.8
Synonyms	(5S)-6-oxo-5-[(4R)-3-oxo-4-[(phenylacetyl)amino]-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]-6-{[(1S)-1-phenylethyl]amino}hexan-1-aminium trifluoroacetate CHEMBL1186489 BDBM50254255
Inchi Key	CJQHVGHBOCFMAH-CZXVKTRTSA-N
Inchi ID	InChI=1S/C34H39N5O3/c1-23(25-14-6-3-7-15-25)36-33(41)31(18-10-11-19-35)39-22-30-27(26-16-8-9-17-28(26)37-30)21-29(34(39)42)38-32(40)20-24-12-4-2-5-13-24/h2-9,12-17,23,29,31,37H,10-11,18-22,35H2,1H3,(H,36,41)(H,38,40)/t23-,29+,31-/m0/s1
PubChem CID	25188220
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50254255
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	452.0 nM	PMID19067538	BindingDB

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