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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	CHEMBL403103
Molecular formula	C16H22N4O
IUPAC name	1-methyl-3-[(4-methyl-3,4-dihydro-1H-quinazolin-2-ylidene)amino]azepan-2-one
Molecular weight	286.379
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.6
Synonyms	BDBM50371978
Inchi Key	CJPGCACCPJLCFS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H22N4O/c1-11-12-7-3-4-8-13(12)18-16(17-11)19-14-9-5-6-10-20(2)15(14)21/h3-4,7-8,11,14H,5-6,9-10H2,1-2H3,(H2,17,18,19)
PubChem CID	136152969
ChEMBL	CHEMBL403103
IUPHAR	N/A
BindingDB	50371978
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	279.0 nM	PMID18023344	BindingDB,ChEMBL

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