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Name | Neurotensin receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | NTSR2 |
Synonym | levocabastine-sensitive neurotensin receptor neurotensin receptor type 2 high-affinity levocabastine-sensitive neurotensin receptor NT2R NTR2 [ Show all ] |
Disease | N/A |
Length | 410 |
Amino acid sequence | METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT |
UniProt | O95665 |
Protein Data Bank | N/A |
GPCR-HGmod model | O95665 |
3D structure model | This predicted structure model is from GPCR-EXP O95665. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2514 |
IUPHAR | 310 |
DrugBank | N/A |
Name | CHEMBL2431125 |
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Molecular formula | C24H28N4O2 |
IUPAC name | 2-cyclobutyl-6-methoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]quinazoline |
Molecular weight | 404.514 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 4.6 |
Synonyms | BDBM50440773 MLS-0463325.0001 SCHEMBL15819562 |
Inchi Key | CIWKHKMZANVYGH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H28N4O2/c1-29-18-10-11-20-19(16-18)24(26-23(25-20)17-6-5-7-17)28-14-12-27(13-15-28)21-8-3-4-9-22(21)30-2/h3-4,8-11,16-17H,5-7,12-15H2,1-2H3 |
PubChem CID | 53245521 |
ChEMBL | CHEMBL2431125 |
IUPHAR | N/A |
BindingDB | 50440773 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <80000.0 nM | PMID24611085 | ChEMBL |
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