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GPCR

NameG-protein coupled receptor 4
SpeciesHomo sapiens (Human)
GeneGPR4
SynonymG-protein coupled receptor 19
GPR19
GPR4
DiseaseN/A
Length362
Amino acid sequenceMGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
UniProtP46093
Protein Data BankN/A
GPCR-HGmod modelP46093
3D structure modelThis predicted structure model is from GPCR-EXP P46093.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3638324
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3675729
Molecular formulaC29H39N5O3
IUPAC nametert-butyl 4-[3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]propanoyl]piperazine-1-carboxylate
Molecular weight505.663
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.2
SynonymsBDBM123494
SCHEMBL12802321
US8748435, 19
Inchi KeyZIKJVMYFESMGDP-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H39N5O3/c1-7-25-24(27-30-20(2)18-21(3)34(27)31-25)19-23-10-8-22(9-11-23)12-13-26(35)32-14-16-33(17-15-32)28(36)37-29(4,5)6/h8-11,18H,7,12-17,19H2,1-6H3
PubChem CID68378975
ChEMBLCHEMBL3675729
IUPHARN/A
BindingDB123494
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC5054.0 nM, NoneBindingDB,ChEMBL

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