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Name | Hydroxycarboxylic acid receptor 2 |
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Species | Mus musculus (Mouse) |
Gene | Hcar2 |
Synonym | Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 360 |
Amino acid sequence | MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR |
UniProt | Q9EP66 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4420 |
IUPHAR | 312 |
DrugBank | N/A |
Name | CHEMBL1208986 |
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Molecular formula | C11H12N4O2 |
IUPAC name | 5-(2-methylpyrazol-3-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid |
Molecular weight | 232.243 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 0.5 |
Synonyms | 5-(2-methylpyrazol-3-yl)-1,4,5,6-tetrahydrocyclopenta[d]pyrazole-3-carboxylic acid GTPL5793 BDBM50323398 compound 8f [PMID: 20615702] SCHEMBL13935754 [ Show all ] |
Inchi Key | ZAJBYTSUTBCMRM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C11H12N4O2/c1-15-9(2-3-12-15)6-4-7-8(5-6)13-14-10(7)11(16)17/h2-3,6H,4-5H2,1H3,(H,13,14)(H,16,17) |
PubChem CID | 12003694 |
ChEMBL | CHEMBL1208986 |
IUPHAR | 5793 |
BindingDB | 50323398 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 450.0 nM | PMID20615702 | BindingDB,ChEMBL |
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