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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	Dibromosalicil
Molecular formula	C14H8Br2O4
IUPAC name	1,2-bis(5-bromo-2-hydroxyphenyl)ethane-1,2-dione
Molecular weight	400.022
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.7
Synonyms	Dibromsalicil Fungotox (VAN) Salicil, 5,5'-dibromo- 5,2'-dihydroxybibenzoyl 639B873 BRN 3384611 DTXSID20200328 MLS002638309 SMR001547796 1,2-bis(5-bromo-2-hydroxyphenyl)-1,2-ethanedione 5,5'-Dibrom-2,2'-dioxybenzil [German] AKOS027382229 cid_10662 Ethanedione, bis(5-bromo-2-hydroxyphenyl)- (9CI) NSC13235 Z2V3FF4B7F 5,5'-Dibromosalicil Bis(5-bromo-2-hydroxyphenyl)ethanedione Dibrosal HMS3086D19 Salicil,5'-dibromo- 5,2'-dioxybenzil AC1L1VOE CTK8J0096 EINECS 208-351-3 NSC 13235 UNII-Z2V3FF4B7F 1,2-bis(5-bromo-2-hydroxyphenyl)ethane-1,2-dione 5,5'-Dibromo-2,2'-dihydroxybenzil BDBM22753 Dibromosalicyl Fungotox Respectol ZINC1683334 5,2'-dihydroxybenzil 523-88-6 Bis-(5-brom-2-hydroxyphenyl)ethandion Dibrosil LS-144117 SCHEMBL2156880 1,2-bis(5-bromo-2-hydroxy-phenyl)ethane-1,2-dione 5,5'-Dibrom-2,2'-dioxybenzil ACM523886 CHEMBL366205 Degermon Ethanedione, bis(5-bromo-2-hydroxyphenyl)- NSC-13235 WLN: QR DE BVVR BQ EE 1,2-Bis-(5-bromo-2-hydroxy-phenyl)-ethane-1,2-dione 5,5'-Dibromo-2,2'-dihydroxybibenzoyl Benzil-based compound, 31 [ Show all ]
Inchi Key	AAOYLOCWJSLLJU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H8Br2O4/c15-7-1-3-11(17)9(5-7)13(19)14(20)10-6-8(16)2-4-12(10)18/h1-6,17-18H
PubChem CID	10662
ChEMBL	CHEMBL366205
IUPHAR	N/A
BindingDB	22753
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	7079.5 nM	PubChem BioAssay data set	ChEMBL

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