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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 3
Species	Homo sapiens (Human)
Gene	LPAR3
Synonym	Lysophosphatidic acid receptor Edg-7 LPA3 receptor LPA-3 LPA receptor 3 endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7 Edg7 [ Show all ]
Disease	Fibrosis
Length	353
Amino acid sequence	MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
UniProt	Q9UBY5
Protein Data Bank	N/A
GPCR-HGmod model	Q9UBY5
3D structure model	This predicted structure model is from GPCR-EXP Q9UBY5.
BioLiP	N/A
Therapeutic Target Database	T95923
ChEMBL	CHEMBL3250
IUPHAR	274
DrugBank	N/A

Ligand

Name	1-Hexadecanoyl-sn-glycero-3-phosphate
Molecular formula	C19H39O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate
Molecular weight	410.488
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.0
Synonyms	Palmitin, 1-mono-, 3-(dihydrogen phosphate), L- 7220-34-0 Hexadecanoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- LysoPA(16:0/0:0) ZINC8219000 CHEBI:15799 NKO 1-Palmitoyl-sn-glyceryl 3-phosphate CTK2H2733 Palmitoyl lysophosphatidic acid (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate AC1O4WBH LMGP10050006 Lysophosphatidic acid(16:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate 1-palmitoyl-sn-glycerol 3-phosphate PA(16:0/0:0) Hexadecanoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester LPA(16:0/0:0) SCHEMBL2935665 (2R)-2-hydroxy-3-(phosphonooxy)propyl palmitate BDBM50430013 Lysophosphatidic acid(16:0/0:0) 1-palmitoyl-sn-glycerol-3-phosphate CHEMBL364797 [ Show all ]
Inchi Key	YNDYKPRNFWPPFU-GOSISDBHSA-N
Inchi ID	InChI=1S/C19H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(21)25-16-18(20)17-26-27(22,23)24/h18,20H,2-17H2,1H3,(H2,22,23,24)/t18-/m1/s1
PubChem CID	6419701
ChEMBL	CHEMBL364797
IUPHAR	N/A
BindingDB	50430013
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	575.44 nM	PMID23395664	ChEMBL
EC50	580.0 nM	PMID23395664	BindingDB,ChEMBL
Intrinsic activity	0.102 -	PMID23395664	ChEMBL

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