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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanin-concentrating hormone receptor 2
Species	Homo sapiens (Human)
Gene	MCHR2
Synonym	G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor MCH2 G protein-coupled receptor 145 MCH-2R MCH receptor 2 GPRv17 GPR145 MCH-R2 [ Show all ]
Disease	N/A
Length	340
Amino acid sequence	MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProt	Q969V1
Protein Data Bank	N/A
GPCR-HGmod model	Q969V1
3D structure model	This predicted structure model is from GPCR-EXP Q969V1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5038
IUPHAR	281
DrugBank	N/A

Ligand

Name	CHEMBL217751
Molecular formula	C19H16F3N3O
IUPAC name	N-(2-aminoquinolin-6-yl)-3-[4-(trifluoromethyl)phenyl]propanamide
Molecular weight	359.352
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.8
Synonyms	BDBM50193697 N-(2-aminoquinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)propanamide ZINC36351894
Inchi Key	AAOYBQGKRBCNLH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H16F3N3O/c20-19(21,22)14-5-1-12(2-6-14)3-10-18(26)24-15-7-8-16-13(11-15)4-9-17(23)25-16/h1-2,4-9,11H,3,10H2,(H2,23,25)(H,24,26)
PubChem CID	44417982
ChEMBL	CHEMBL217751
IUPHAR	N/A
BindingDB	50193697
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>50.0 %	PMID16919456	ChEMBL

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