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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS002701634
Molecular formula	C20H12O3
IUPAC name	4-(2-hydroxynaphthalen-1-yl)naphthalene-1,2-dione
Molecular weight	300.313
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.6
Synonyms	4-(2-hydroxy-1-naphthyl)-1,2-naphthoquinone BDBM80753 EU-0033338 NSC102539 4-(2-oxidanylnaphthalen-1-yl)naphthalene-1,2-dione CBMicro_013403 SMSF0004113 2'-hydroxy-1,1'-binaphthalene-3,4-dione AC1L6EYQ cid_265898 NSC-102539 ZINC1674769 4-(2-hydroxy-1-naphthyl)naphthalene-1,2-dione BIM-0013151.P001 MCULE-4725065735 NSC628930 MolPort-002-134-455 SR-01000197677 4-(2-hydroxy-1-naphthalenyl)naphthalene-1,2-dione AKOS001582520 CTK7H0699 NSC-628930 [1,1'-Binaphthalene]-3,4-dione, 2'-hydroxy- 4-(2-hydroxynaphthalen-1-yl)naphthalene-1,2-dione CB02984 MLS-0440187.0001 SMR001565235 AB00074882-01 CHEMBL1721095 NCI60_009373 SR-01000197677-1 [ Show all ]
Inchi Key	CEFYNLRCBQRIBG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H12O3/c21-17-10-9-12-5-1-2-6-13(12)19(17)16-11-18(22)20(23)15-8-4-3-7-14(15)16/h1-11,21H
PubChem CID	265898
ChEMBL	CHEMBL1721095
IUPHAR	N/A
BindingDB	80753
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<3325.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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