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GPCR

NameBeta-2 adrenergic receptor
SpeciesCavia porcellus (Guinea pig)
GeneAdrb2
SynonymBeta-2 adrenoceptor
Beta-2 adrenoreceptor
DiseaseN/A for non-human GPCRs
Length418
Amino acid sequenceMGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
UniProtQ8K4Z4
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5414
IUPHARN/A
DrugBankN/A

Ligand

NameCID 44285227
Molecular formulaC13H24N2O6
IUPAC name(E)-but-2-enedioic acid;(3E)-1-(tert-butylamino)-3-ethoxyiminopropan-2-ol
Molecular weight304.343
Hydrogen bond acceptor8
Hydrogen bond donor4
XlogPNone
SynonymsN/A
Inchi KeyCEDAETXCGKHVTR-AXGWIPDMSA-N
Inchi IDInChI=1S/C9H20N2O2.C4H4O4/c1-5-13-11-7-8(12)6-10-9(2,3)4;5-3(6)1-2-4(7)8/h7-8,10,12H,5-6H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b11-7+;2-1+
PubChem CID44285227
ChEMBLCHEMBL39987
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC50977.24 nMPMID7910217ChEMBL

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