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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	CHEMBL2030161
Molecular formula	C28H30N2O3S
IUPAC name	ethyl 3-[[4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioyl]amino]benzoate
Molecular weight	474.619
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	5.0
Synonyms	BDBM50384199 SCHEMBL15919676
Inchi Key	AEXOPXROZSKCGV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H30N2O3S/c1-2-33-26(31)21-10-9-15-25(20-21)29-27(34)30-18-16-24(17-19-30)28(32,22-11-5-3-6-12-22)23-13-7-4-8-14-23/h3-15,20,24,32H,2,16-19H2,1H3,(H,29,34)
PubChem CID	70687926
ChEMBL	CHEMBL2030161
IUPHAR	N/A
BindingDB	50384199
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	238.0 nM	PMID22607676	BindingDB,ChEMBL

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