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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	Kinetin riboside
Molecular formula	C15H17N5O5
IUPAC name	(2R,3R,4S,5R)-2-[6-(furan-2-ylmethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Molecular weight	347.331
Hydrogen bond acceptor	9
Hydrogen bond donor	4
XlogP	0.2
Synonyms	ADENOSINE, N-FURFURYL- CAGLGYNQQSIUGX-SDBHATRESA-N FT-0621143 KBio3_002022 MFCD00037987 N6-(2-ss>>a<<(1/4)x>>u)IUUO NSC 120958 SpecPlus_000551 ST057091 4-26-00-03686 (Beilstein Handbook Reference) BDBM50241447 KB-55460 Kinetin ribonucleoside N-(2-Furanylmethyl)-1H-purin-6-amine riboside NCGC00017361-03 SCHEMBL3190252 Spectrum4_001930 (2R,3R,4S,5R)-2-(6-(furan-2-ylmethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol 6- inverted question mark.>>u degrees +/->>uaNssE masculineEUO AC1L2G2M BRN 0059588 DivK1c_006647 KBio2_004325 Kinetin-9-riboside N6-(2-Furanyl-methyl)adenosine NCGC00142491-02 SMR001223878 SR-05000002609 (2R,3R,4S,5R)-2-{6-[(furan-2-ylmethyl)amino]purin-9-yl}-5-(hydroxymethyl)oxolane-3,4-diol Adenosine,N-(2-furanylmethyl)- CCG-38867 Furfuryladenosine KBioGR_002280 MLS002207023 N6-Furfuryladenosine Riboside, kinetin Spectrum2_001453 (-)-KINETIN RIBOSIDE ZINC2169849 4338-47-0 BRD-K94325918-001-02-0 CHEMBL411066 KBio1_001591 N-(2-Furanylmethyl)adenosine NCGC00017361-04 SDCCGMLS-0066656.P001 Spectrum5_000687 (2R,3R,4S,5R)-2-(6-(furan-2-ylmethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 6-Furfuryladenosine Adenosine, N-(2-furanylmethyl)- (9CI) BSPBio_002802 EINECS 224-389-3 KBio2_006893 LS-15141 N6-(2-furanylmethyl)-adenosine NCGC00142491-03 SPBio_001345 SR-05000002609-1 (3S,2R,4R,5R)-5-{6-[(2-furylmethyl)amino]purin-9-yl}-2-(hydroxymethyl)oxolane- 3,4-diol AKOS024282559 CHEBI:95050 HY-101055 KBioSS_001757 N(sup 6)-Furfuryladenosine NCGC00017361-02 Ribosylkinetin Spectrum3_001101 (2R,3R,4S,5R)-2-(6-((Furan-2-ylmethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 6-Furfurylaminopurine riboside BRD-K94325918-001-05-3 CS-6377 KBio2_001757 Kinetin riboside, proapoptotic anitproliferative plant growth regulator N6- inverted question mark.>>uIUUO NCGC00142491-01 SMP1_000170 Spectrum_001277 (2R,3R,4S,5R)-2-[6-(furan-2-ylmethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol [ Show all ]
Inchi Key	CAGLGYNQQSIUGX-SDBHATRESA-N
Inchi ID	InChI=1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1
PubChem CID	20345
ChEMBL	CHEMBL411066
IUPHAR	N/A
BindingDB	50241447
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	5011.9 nM	PubChem BioAssay data set	ChEMBL

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